Methylation-associated mutagenesis is the main driver of variation in mutation spectra across eukaryotes. Analysis of 108 species from animals to plants shows CpG cytosine mutation rates explain mutation patterns and almost perfectly predict genome-wide CpG depletion.

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\nThe study was funded by the Arc Institute, the National Institutes of Health (grants NIH DK019525, T32AG000255, F30AG081097, T32HG000046, F30AG080958, DP2-AG-067511, DP2-AG-067492, DP1-DK-140021, R01-NS-134976 and R01-DK-129691), the Burroughs Wellcome Fund, the American Cancer Society, the Pew Scholar Award, the Searle Scholar Program, the Edward Mallinckrodt Jr. Foundation, the W.W. Smith Charitable Trust, the Blavatnik Family Fellowship, the Prevent Cancer Foundation, the Polybio Research Foundation, the V Foundation, the Kathryn W. Davis Aging Brain Scholar Program, the McKnight Brain Research Foundation, the Kenneth Rainin Foundation, the IDSA Foundation and the Human Frontier Science Program.,更多细节参见手游

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